The CPS-NSF LARGE: Science of Integration for Cyber Physical Systems project by Vanderbilt University, University of Maryland, and University of Notre Dame, in collaboration with General Motors Corporation held its Principal Investigator's kickoff meeting November 29th and 30th, 2010.  The meeting was held at the Vanderbilt University School of Engineering's Institute for Software Integrated Systems offices in Nashville, TN. Representatives from the National Science Foundation (NSF), DARPA, NRC, and ONR attended in addition to collaborators from the participating universities and industry leaders.