Developers of information systems have always utilized various visual formalisms during the
design process, albeit in an informal manner. Architecture diagrams, finite state machines,
and signal flow graphs are just a few examples. Model Integrated Computing (MIC) is an
approach that considers these design artifacts as first class models and uses them to generate
the system or subsystems automatically. Moreover, the same models can be used to analyze
the system and generate test cases and documentation. MIC advocates the formal definition of
these formalisms, called domain-specific modeling languages (DSML), via metamodeling and
the automatic configuration of modeling tools from the metamodels. However, current MIC
infrastructures are based on desktop applications that support a limited number of platforms,
discourage concurrent design collaboration and are not scalable. This paper presents WebGME, a cloud- and web-based cyberinfrastructure to support the collaborative modeling, analysis, and synthesis of complex, large-scale scientific and engineering information systems. It facilitates interfacing with existing external tools, such as simulators and analysis tools, it provides custom domain-specific visualization support and enables the creation of automatic code generators.